SYMEX CML500

The Symex CML 500 is a high-performance vacuum homogenizing mixer designed for the production of demanding products in the pharmaceutical and cosmetic industries.

The system combines mixing, dispersing, homogenizing, heating, cooling and vacuum processing in a closed vessel, ensuring precise and reproducible production results – from pilot scale to industrial manufacturing.

Symex CML 500 – Condition & Availability

✔ This machine (Symex CML500) has already been sold. Currently available: Symex CML125, Symex P1000 and more used homogenizer mixers.

✔ Industrial unit in pharmaceutical design
✔ Pressure- and vacuum-rated mixing vessel
✔ Overhauled by SYMEX
✔ Documentation available (incl. technical files)
✔ Already sold

Why choose a Symex CML 500?

The CML 500 is a proven solution for demanding processes:

✔ Fully integrated vacuum homogenizing mixer
✔ Suitable for high-viscosity and complex products
✔ Precise process control for reproducible results
✔ Combination of anchor agitator and high-performance homogenizer
✔ Hygienic, CIP-capable design
✔ Ideal for production and scale-up

Typical Applications

The Symex CML 500 is ideally suited for:

• Cosmetic creams and lotions
• Pharmaceutical products (ointments, gels)
• Emulsions (O/W and W/O)
• Suspensions
• Toothpastes and pastes

Homogenizing mixers are typically used to create stable emulsions and fine particle distributions.

Process Functions of the CML 500

The CML 500 is a complete process system integrating:

• Mixing
• Dispersing
• Homogenizing
• Heating and cooling
• Vacuum processing
• CIP cleaning

All process steps take place in a closed system – ensuring maximum process reliability and product quality.

Vessel

• Usable volume: approx. 500 liters
• Total volume: approx. 780 liters
• Minimum volume: approx. 125–160 liters
• Product pressure range: -1 / +2 bar
• Product temperature: up to approx. 133 °C
• Jacket: up to +4 bar / 151 °C
• Design according to AD 2000

The vessel is fully pressure- and vacuum-rated, allowing safe operation under demanding process conditions.

Agitator

• Anchor agitator with baffles
• Speed range: approx. 11–66 rpm
• Power: approx. 7.5 kW
• Frequency-controlled
• Designed for high-viscosity products

The agitator ensures uniform mixing and optimal heat transfer.

Homogenizer

• Power: approx. 16–20 kW
• Speed: up to approx. 3,000 rpm
• High shear forces for fine dispersion
• Rotor/stator system

The homogenizer ensures stable emulsions and consistent product quality.

Vacuum System

• Vacuum operation possible
• Liquid ring vacuum pump (external)
• Pressure and vacuum monitoring

Vacuum processing reduces air inclusion and significantly improves product quality.

Heating & Cooling

• Double jacket vessel (2-zone heating)
• Precise temperature control
• Uniform heat distribution

CIP System

• Multiple CIP connections
• Rotating spray nozzles (360°)
• Cleaning of vessel and piping

Raw Material Feeding

• Direct suction of liquids and powders
• Feeding into the homogenizer area
• Fast and efficient processing

Integrated feeding and recirculation systems enable highly efficient process control.

Delivery & Handling

• Ex-Works delivery
• Turnkey project available (including commissioning)
• 12-month warranty (excluding wear parts)
• International shipping available

Looking for a similar machine?

We can help you source a comparable machine – contact us now for a free, no-obligation enquiry:

📧 info@s-vt.net
Please provide your complete company details.

Currently available alternatives to the Symex CML500

The Symex CML500 has been sold. The following used machines are available at short notice and can be inspected in Weyhe near Bremen, Germany:

• Becomix RW2500 + AB1200 – homogenizing mixer for large batches with pre-mix vessel
• Becomix RW320 – homogenizing mixer, approx. 100–320 L, GMP, CIP/SIP
• Symex P1000 – pharma storage tank / agitated vessel 1,000 L (2 units)

See all offers in our overview of used homogenizing mixers & process equipment.

Frequently Asked Questions about the Symex CML500

Is the Symex CML500 still available?

No, this machine has already been sold. The technical data on this page is provided for reference, e.g. when looking for a comparable machine.

What were the key specifications of the Symex CML500?

Working volume approx. 500 L (min. approx. 125–160 L), total volume approx. 780 L, product chamber -1/+2 bar, up to approx. 133 °C, anchor agitator with baffles (approx. 11–66 rpm, 7.5 kW), homogenizer approx. 16–20 kW, AD 2000 design.

What alternatives to the Symex CML500 are available?

Currently available are, among others, Becomix RW2500 + AB1200, Becomix RW320, Symex P1000. We are happy to advise which machine suits your product, batch size and GMP requirements.

Can you source a comparable used machine?

Yes. With our procurement support we search specifically for a suitable used vacuum homogenizing mixer. Tell us your product, required volume, viscosity and requirements such as GMP, CIP/SIP or explosion protection – by phone at +49 4203 789492 or by email to info@s-vt.net.

This is a non-binding offer from SEEFRIED Verfahrenstechnik GmbH as an independent supplier.
There is no business relationship with the manufacturer.

All trademarks mentioned are the property of their respective owners and are used solely for the purpose of identifying the products offered.

This is not an offer from the manufacturer.